Tsuchiya T, Horii I
Shiseido Research Center, Yokohama, Japan.
Psychoneuroendocrinology. 1995;20(1):95-102. doi: 10.1016/0306-4530(94)00047-6.
Time-course variations in plasma testosterone levels after various periods of immobilization stress (10 min, 30 min, 2 h, 6 h) were examined in male Syrian hamsters. The immobilization stress consisted of placing the animals in a prone position and wrapping them with flexible steel wire gauze. This was done at room temperature. Testosterone levels were determined in blood samples taken after the hamsters were decapitated. Chronic (2 h, 6 h) immobilization stress produced a drastic and enduring fall in plasma testosterone levels. Reduction of plasma testosterone following the 6-h immobilization stress was observed even 18 h after the stress had been relieved. However, acute (10 min, 30 min) immobilization stress did not influence plasma testosterone. These findings indicated that the effect of immobilization stress on plasma testosterone in hamsters was not biphasic, which it is in rats. Further, these results suggest that immobilization stress in hamsters would be a valuable technique with which to investigate the effects of physiological ranges of testosterone on physiological and psychological functions.
在雄性叙利亚仓鼠中，研究了不同时长（10分钟、30分钟、2小时、6小时）的固定应激后血浆睾酮水平的时程变化。固定应激包括将动物置于俯卧位并用柔性钢丝网包裹。这一操作在室温下进行。在仓鼠断头后采集的血样中测定睾酮水平。慢性（2小时、6小时）固定应激导致血浆睾酮水平急剧且持久下降。在应激解除18小时后，仍观察到6小时固定应激后血浆睾酮水平降低。然而，急性（10分钟、30分钟）固定应激并未影响血浆睾酮水平。这些发现表明，固定应激对仓鼠血浆睾酮的影响并非像对大鼠那样呈双相性。此外，这些结果表明，仓鼠的固定应激将是一种有价值的技术，可用于研究睾酮生理范围内对生理和心理功能的影响。
