Shore A C, Sandeman D D, Tooke J E
Department of Vascular Medicine, Postgraduate Medical School, University of Exeter, United Kingdom.
Am J Physiol. 1995 Jan;268(1 Pt 2):H147-54. doi: 10.1152/ajpheart.1995.268.1.H147.
The influence of gender, local temperature, and systemic blood pressure on human capillary pressure is unknown. Finger nail fold capillary pressure was therefore directly measured in 74 healthy supine volunteers (40 female) at midaxillary level. Capillary pressure was lower in women than in men (15.9 +/- 3.0 vs. 18.2 +/- 2.3 mmHg; P = 0.001), particularly in premenopausal women, but was not related to systolic, diastolic, or mean blood pressure. Capillary pulse pressure amplitude was related to skin temperature, an effect more marked in women (P = 0.003). There was a significant association between skin temperature and the time taken for the systolic pressure rise to reach the capillary, in women only (r = -0.69, P < 0.001). Increasing age reduced the high-frequency waves in the pressure waveform [2nd harmonic percentage of fundamental: r = -0.52 and P = 0.002 (women), r = -0.52 and P = 0.004 (men)]. Thus mean capillary pressure and the pressure waveform may be influenced by gender, age, and skin temperature, illustrating the necessity to adequately match control groups during assessments of capillary pressure pathophysiology.
性别、局部温度和全身血压对人体毛细血管压力的影响尚不清楚。因此，对74名健康仰卧志愿者（40名女性）在腋中线水平直接测量了甲襞毛细血管压力。女性的毛细血管压力低于男性（15.9±3.0对18.2±2.3 mmHg；P = 0.001），尤其是绝经前女性，但与收缩压、舒张压或平均血压无关。毛细血管脉压幅度与皮肤温度有关，这种效应在女性中更为明显（P = 0.003）。仅在女性中，皮肤温度与收缩压上升至毛细血管所需时间之间存在显著关联（r = -0.69，P < 0.001）。年龄增长会降低压力波形中的高频波[基波的二次谐波百分比：r = -0.52，P = 0.002（女性），r = -0.52，P = 0.004（男性）]。因此，平均毛细血管压力和压力波形可能受性别、年龄和皮肤温度的影响，这表明在评估毛细血管压力病理生理学过程中充分匹配对照组的必要性。
