Mahy I R, Shore A C, Smith L D, Tooke J E
Department of Vascular Medicine, Postgraduate Medical School, University of Exeter, UK.
Int J Microcirc Clin Exp. 1994 Sep-Oct;14(5):257-61. doi: 10.1159/000178837.
The importance of the dynamic nature of perfusion pressure within the peripheral microcirculation is increasingly recognised. Capillary pressure is determined not only by arterial inflow pressure, but is also subject to a variety of local and systemic influences which have been shown to affect both mean pressure and the capillary pulse waveform. To what extent changes in central pulse waveform influence capillary pressure has yet to be determined. By using a dynamic technique of capillary pressure measurement in human subjects with aortic stenosis, we have been able to show that the characteristics of the pulse waveform typically associated with large vessels in this condition are also readily detectable at a capillary level despite local influences. However, changes in the rate of pulse wave transmission described in large arteries were not apparent at a microvascular level. Unlike mean capillary pressure and capillary pulse pressure, pulse waveform in the capillary mimics central haemodynamics.
外周微循环中灌注压动态特性的重要性日益受到认可。毛细血管压不仅取决于动脉流入压，还受到多种局部和全身影响，这些影响已被证明会影响平均压力和毛细血管脉搏波形。中心脉搏波形的变化在多大程度上影响毛细血管压尚待确定。通过对患有主动脉瓣狭窄的人体受试者采用动态毛细血管压测量技术，我们已经能够证明，在这种情况下通常与大血管相关的脉搏波形特征，尽管存在局部影响，但在毛细血管水平也很容易检测到。然而，大动脉中描述的脉搏波传播速度变化在微血管水平并不明显。与平均毛细血管压和毛细血管脉压不同，毛细血管中的脉搏波形模仿中心血流动力学。
