两种新型甘氨酰环素（米诺环素和6-去甲基-6-脱氧四环素的N，N-二甲基甘氨酰酰胺衍生物）对339株厌氧菌的体外活性。
In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria.
作者信息
Wexler H M, Molitoris E, Finegold S M
机构信息
Medical Service, Veterans Administration Medical Center, West Los Angeles, California 90073.
出版信息
Antimicrob Agents Chemother. 1994 Oct;38(10):2513-5. doi: 10.1128/AAC.38.10.2513.
The in vitro activities of the N,N-dimethylglycylamido derivatives of minocycline (DMG-MINO) and 6-demethyl-6-deoxytetracycline (DMG-DMDOT) were compared with those of minocycline, tetracycline, clindamycin, and metronidazole by using the National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution method. The MICs of DMG-MINO, DMG-DMDOT, and metronidazole at which 90% of the strains were susceptible (0.5, 1, and 1 micrograms/ml, respectively) were lower than those for clindamycin, minocycline, and tetracycline (4, 8, and 32 micrograms/ml, respectively). All of the strains of anaerobes tested, except one strain of Bacteroides ovatus (MIC, 16 micrograms/ml), were susceptible to DMG-MINO and DMG-DMDOT at 8 micrograms/ml.
采用美国国家临床实验室标准委员会认可的沃兹沃思琼脂稀释法，比较了米诺环素的N，N - 二甲基甘氨酰胺衍生物（DMG - MINO）和6 - 去甲基 - 6 - 脱氧四环素（DMG - DMDOT）与米诺环素、四环素、克林霉素和甲硝唑的体外活性。DMG - MINO、DMG - DMDOT和甲硝唑对90%菌株敏感的最低抑菌浓度（分别为0.5、1和1微克/毫升）低于克林霉素、米诺环素和四环素（分别为4、8和32微克/毫升）。除1株卵形拟杆菌（最低抑菌浓度为16微克/毫升）外，所有受试厌氧菌菌株对8微克/毫升的DMG - MINO和DMG - DMDOT均敏感。
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