淋病奈瑟菌对甘氨酰环素类药物的敏感性。
Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines.
作者信息
Whittington W L, Roberts M C, Hale J, Holmes K K
机构信息
Department of Medicine, University of Washington, Seattle 98195, USA.
出版信息
Antimicrob Agents Chemother. 1995 Aug;39(8):1864-5. doi: 10.1128/AAC.39.8.1864.
Abstract
To assess the activities of two glycylcyclines, N,N-dimethylglycylamido (DMG) derivatives of minocycline (MINO) and 6-demethyl-6-deoxytetracycline (DMDOT), 203 gonococcal isolates recovered at six sexually transmitted disease clinics in the western United States were evaluated. Antimicrobial susceptibilities to tetracycline HCl, doxycycline, MINO, DMG-DMDOT, and DMG-MINO were determined by agar dilution tests. DMG-DMDOT and DMG-MINO were more active than tetracycline HCl, doxycycline, or MINO regardless of the presence of Tet M or of chromosomal mutations mediating tetracycline resistance (P < 0.001).
摘要
为评估两种甘氨酰环素（米诺环素（MINO）和6-去甲基-6-脱氧四环素（DMDOT）的N，N-二甲基甘氨酰胺（DMG）衍生物）的活性，对在美国西部六家性传播疾病诊所分离出的203株淋球菌进行了评估。通过琼脂稀释试验测定了对盐酸四环素、多西环素、米诺环素、DMG-DMDOT和DMG-MINO的抗菌敏感性。无论是否存在Tet M或介导四环素耐药性的染色体突变，DMG-DMDOT和DMG-MINO都比盐酸四环素、多西环素或米诺环素更具活性（P < 0.001）。
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