Yvon M, Beucher S, Guilloteau P, Le Huerou-Luron I, Corring T
INRA, Laboratoire de Recherches Laitières, Jouy-en-Josas, France.
Reprod Nutr Dev. 1994;34(6):527-37. doi: 10.1051/rnd:19940602.
Caseinomacropeptide (CMP) is a 64-amino-acid-residue peptide which is released from kappa-casein by gastric proteinases. This review sums up the knowledge concerning its effects on the digestive function. Part 1 recalls the origin and heterogeneity of CMP. Here we underline that there are various forms of CMP which differ by their glycosylation level and genetic mutation. Consequently the forms used for studying biological activities need to be defined accurately. Part 2 summarizes the effects of CMP on digestive secretions. The major effect is an inhibitory effect on acid gastric secretions. Simultaneously, the blood concentration of regulatory digestive peptides is modified. In part 3 we try to clarify the mechanisms of action of CMP. A slightly glycosylated form of CMP, the A variant, appears to be responsible for the biological activity. Evidence suggests that CMP triggers stimuli from intestinal receptors without being absorbed. The signal would be then transmitted to organs through regulatory digestive peptides.
酪蛋白巨肽（CMP）是一种由胃蛋白酶从κ-酪蛋白释放出来的含64个氨基酸残基的肽。这篇综述总结了关于其对消化功能影响的知识。第一部分回顾了CMP的起源和异质性。在此我们强调，存在多种形式的CMP，它们在糖基化水平和基因突变方面有所不同。因此，用于研究生物活性的形式需要准确界定。第二部分总结了CMP对消化液分泌的影响。主要作用是对胃酸分泌产生抑制作用。同时，调节性消化肽的血药浓度会发生改变。在第三部分中，我们试图阐明CMP的作用机制。CMP的一种轻度糖基化形式，即A变体，似乎是生物活性的原因。有证据表明，CMP在未被吸收的情况下触发肠道受体的刺激。然后该信号将通过调节性消化肽传递到各个器官。
