Kong N C, Nasruruddin B A, Murad S, Ong K J, Sukumaran K D
Department of Medicine, National University of Malaysia, Kuala Lumpur.
Lupus. 1994 Oct;3(5):393-5. doi: 10.1177/096120339400300505.
Many studies have shown an association between human leucocyte antigens (HLA) and systemic lupus erythematosus (SLE) in the various study populations. Although SLE is not an uncommon disease in the Malaysian Archipelago, and appears to affect all three major racial groups equally (i.e. Southern Chinese, Malays and Southern Indians), very little information is available on the HLA profiles in the two latter groups. In phase I of our study of the HLA profiles in Malaysian SLE patients, the HLA phenotypes (class I: A, B, C; Class II: DR, DQ) of Malay patients with confirmed SLE and 91 normal Malay controls were determined using the microcytotoxicity assay. The strong association between DR (RR 3.28, P = 0.008) concurs with that reported among Chinese and Japanese populations. Moderate to strong associations with HLA-B 7 (RR 4.99, P = 0.02) and Cw 7 (RR 2.94, P = 0.003) were also found. We believe this is the first report of the association of HLA and SLE in the Malay population.
许多研究表明，在不同的研究人群中，人类白细胞抗原（HLA）与系统性红斑狼疮（SLE）之间存在关联。尽管SLE在马来西亚群岛并非罕见疾病，且似乎对所有三大主要种族群体（即华裔、马来人和印度裔）的影响相同，但关于后两个群体的HLA谱的信息却非常少。在我们对马来西亚SLE患者HLA谱的研究的第一阶段，使用微量细胞毒性试验确定了确诊为SLE的马来患者和91名正常马来对照的HLA表型（I类：A、B、C；II类：DR、DQ）。DR（相对危险度3.28，P = 0.008）之间的强关联与在中国和日本人群中报道的一致。还发现与HLA - B7（相对危险度4.99，P = 0.02）和Cw7（相对危险度2.94，P = 0.003）存在中度至强关联。我们认为这是关于马来人群中HLA与SLE关联的首次报告。
