马来西亚人的人类白细胞抗原与鼻咽癌
HLA and nasopharyngeal carcinoma in Malays.
作者信息
Chan S H, Chew C T, Prasad U, Wee G B, Srinivasan N, Kunaratnam N
出版信息
Br J Cancer. 1985 Mar;51(3):389-92. doi: 10.1038/bjc.1985.52.
Abstract
HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC, was also increased among Malay NPC (13/45 29%) compared to controls (18/167 11%; P = 0.003, Pc = 0.07 RR = 3.4). Similar to the findings among Chinese NPC, the frequency of B17 was higher in early onset (less than or equal to 30 years) Malay NPC resulting in a higher relative risk (RR = 5.0).
摘要
在不相关的马来鼻咽癌（NPC）患者中观察到HLA相关性。在45例马来NPC患者中有18例（40%）观察到HLA - B18，而在167例马来正常人中有22例（13%）观察到（P = 0.0001；Pc = 0.0027，RR = 4.4）。与中国NPC相关的抗原之一HLA - B17在马来NPC患者中的频率（45例中有13例，29%）也高于对照组（167例中有18例，11%；P = 0.003，Pc = 0.07，RR = 3.4）。与中国NPC的研究结果相似，早发型（小于或等于30岁）马来NPC中B17的频率更高，导致相对风险更高（RR = 5.0）。
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