系统性红斑狼疮患者手部的变形性关节病与抗SSA/Ro和抗SSB/La抗体相关。

Deforming arthropathy of the hands in systemic lupus erythematosus is associated with antibodies to SSA/Ro and to SSB/La.

作者信息

Franceschini F, Cretti L, Quinzanini M, Rizzini F L, Cattaneo R

机构信息

Clinical Immunology Unit, Spedali Civili, University of Brescia, Italy.

出版信息

Lupus. 1994 Oct;3(5):419-22. doi: 10.1177/096120339400300510.

DOI:10.1177/096120339400300510

PMID:7841997

Abstract

Thirteen patients with systemic lupus erythematosus and deforming arthropathy (DA) of the hands were compared with 111 patients with SLE without deforming arthropathy. Clinical features were comparable in the two groups. Patients fulfilling criteria for mixed connective tissue disease (MCTD) were not included in the present study. A higher prevalence of antibodies to SSA/Ro (P < 0.0125) and SSB/La (P < 0.004) were found in the SLE-DA group. The detection of antibodies to SSA/Ro and SSB/La was even more strictly associated with DA in SLE antibodies to SSA/Ro alone (P < 0.002). Regarding the fine specificity of anti-SSA/Ro, a prevalent response to the 52 kD protein of the Ro antigen was found. We conclude that patients with SLE developing deformities of the hands belong to a subset of patients with circulating antibodies to SSA/Ro, particularly to the 52 kD component, and to SSB/La.

摘要

将13例患有系统性红斑狼疮且手部出现变形性关节病（DA）的患者与111例无手部变形性关节病的系统性红斑狼疮患者进行了比较。两组的临床特征具有可比性。符合混合性结缔组织病（MCTD）标准的患者未纳入本研究。在系统性红斑狼疮-变形性关节病（SLE-DA）组中发现抗SSA/Ro抗体（P < 0.0125）和抗SSB/La抗体（P < 0.004）的患病率更高。单独检测抗SSA/Ro抗体时，抗SSA/Ro和抗SSB/La抗体的检测与系统性红斑狼疮中的变形性关节病关联更为紧密（P < 0.002）。关于抗SSA/Ro的精细特异性，发现对Ro抗原的52 kD蛋白存在普遍反应。我们得出结论，患有手部畸形的系统性红斑狼疮患者属于循环中存在抗SSA/Ro抗体（特别是52 kD成分）和抗SSB/La抗体的患者亚组。