Leach M O
CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Surrey, UK.
Technol Health Care. 1994 Dec;2(4):235-46.
Magnetic resonance spectroscopy provides a means of non-invasively measuring the behaviour of a range of compounds of biochemical significance. With the development of a range of spatial localization and mapping techniques, the method has a range of promising applications in oncology. 31P and 1H spectroscopy are of value in observing the metabolism of both tumours and normal tissues. 19F spectroscopy has been used to monitor the metabolism of fluorine containing anticancer drugs, and 13C may find application in this field, particularly in pre-clinical studies. In vivo clinical measurements are complemented by pre-clinical studies, high resolution measurements of extracts from tissue samples and also the measurement of biofluids, which can provide additional metabolic and pharmacokinetic information. The application of these techniques to oncology is reviewed, with particular emphasis on their clinical role.
磁共振波谱提供了一种非侵入性测量一系列具有生化意义的化合物行为的方法。随着一系列空间定位和映射技术的发展，该方法在肿瘤学领域有一系列有前景的应用。31P和1H波谱在观察肿瘤和正常组织的代谢方面具有价值。19F波谱已用于监测含氟抗癌药物的代谢，13C可能在该领域得到应用，特别是在临床前研究中。临床前研究、组织样本提取物的高分辨率测量以及生物流体的测量对体内临床测量起到补充作用，这些测量可以提供额外的代谢和药代动力学信息。本文综述了这些技术在肿瘤学中的应用，尤其强调了它们的临床作用。
