Daly P F, Cohen J S
Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Cancer Res. 1989 Feb 15;49(4):770-9.
The development of nuclear magnetic resonance (NMR) spectroscopy as an established research tool for noninvasive studies of cancer cells and for in vivo studies of tumors in animals and humans has led to the possibility that this technique may be used in the future for clinical research studies and monitoring of therapy in cancer patients in combination with magnetic resonance imaging. This article provides a brief qualitative explanation of NMR spectroscopy and then reviews the cell and animal studies detailing which biochemicals can be observed in vivo by 31P, 13C, and 1H NMR. The human studies done to date and their potential for diagnosis and monitoring of therapy are then discussed. In addition, 19F NMR spectroscopic studies of fluorinated drugs and 1H and 31P NMR studies relating to drug resistance are mentioned. The current technical limitations and developing improvements are indicated also.
核磁共振（NMR）光谱作为一种用于癌细胞无创研究以及动物和人类肿瘤体内研究的成熟研究工具的发展，使得该技术未来有可能与磁共振成像相结合，用于癌症患者的临床研究和治疗监测。本文对NMR光谱进行了简要的定性解释，然后回顾了细胞和动物研究，详细介绍了通过31P、13C和1H NMR在体内可观察到的生物化学物质。接着讨论了迄今为止所做的人体研究及其在诊断和治疗监测方面的潜力。此外，还提到了含氟药物的19F NMR光谱研究以及与耐药性相关的1H和31P NMR研究。同时也指出了当前的技术局限性和正在取得的进展。
