Hans P, Martin C
Service Universitaire d'Anesthésie-Réanimation, CHR de la Citadelle, Liège, Belgique.
Cah Anesthesiol. 1994;42(4):521-4.
In severe head-injured patients, intravenous sedation is an integrant part of therapy. Its main objectives consist in facilitation of ventilation and other therapeutic procedures but also more specifically in the control of intracranial pressure and epileptic seizures. The ideal sedative drug must fulfil a number of criteria regarding pharmacokinetics, cerebral metabolism and hemodynamics. Opioids, midazolam and propofol are the most commonly used sedative drugs. The therapeutic response and the neurological status of the patients are the guidelines for the choice, the duration and the assessment of sedation.
在重度颅脑损伤患者中，静脉镇静是治疗的一个组成部分。其主要目的在于促进通气及其他治疗操作，但更具体地说还在于控制颅内压和癫痫发作。理想的镇静药物必须在药代动力学、脑代谢和血流动力学方面满足一些标准。阿片类药物、咪达唑仑和丙泊酚是最常用的镇静药物。患者的治疗反应和神经状态是选择、确定镇静持续时间及评估镇静效果的指导依据。
