[降钙素和吲哚美辛对白细胞介素-1介导的骨吸收的影响]
[Effects of calcitonin and indomethacin on bone resorption mediated by interleukin-1].
作者信息
Zhang W Z, Yu S F, Zheng L F
机构信息
Department of Oral Pathology, School of Stomatology, Beijing Medical University.
出版信息
Zhonghua Yi Xue Za Zhi. 1994 Sep;74(9):530-2, 581-2.
The effects of calcitonin and indomethacin on bone resorption stimulated by interleukin-1 (IL-1) were studied in cultured neonatal mouse calvariae. The results showed that calcium release from cultured calvariae was significantly increased after adding 20 ng/ml IL-1 (P < 0.01). The increase of calcium release stimulated by IL-1 was blocked by both calcitonin at the concentration of 10, 100, 1,000 ng/ml and indomethacin (10(-6), 10(-5) mol/L). The stimulation of calcium release by IL-1 was also blocked even adding 10 mol/L indomethacin 5 hours after adding IL-1 into the culture. These data showed that both calcitonin and indomethacin can inhibit bone resorption stimulated by IL-1. Thus, it is possible that calcitonin and indomethacin may be used as a therapeutic agent to block inflammatory bone resorption mediated by IL-1.
在培养的新生小鼠颅骨中研究了降钙素和吲哚美辛对白细胞介素-1（IL-1）刺激的骨吸收的影响。结果显示，加入20 ng/ml IL-1后，培养颅骨的钙释放显著增加（P < 0.01）。浓度为10、100、1000 ng/ml的降钙素和吲哚美辛（10⁻⁶、10⁻⁵ mol/L）均能阻断IL-1刺激的钙释放增加。在向培养物中加入IL-1 5小时后，即使加入10 mol/L吲哚美辛，IL-1对钙释放的刺激也被阻断。这些数据表明，降钙素和吲哚美辛均能抑制IL-1刺激的骨吸收。因此，降钙素和吲哚美辛有可能用作阻断由IL-1介导的炎症性骨吸收的治疗剂。
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