Weisenhorn D M, Prieto E W, Celio M R
Institute of Histology and General Embryology, University Pérolles, Switzerland.
Brain Res Dev Brain Res. 1994 Oct 14;82(1-2):293-7. doi: 10.1016/0165-3806(94)90171-6.
In order to be able to study the still disputed fate and function of the large Cajal-Retzius cells in the marginal zone (prospective layer I) during corticogenesis, it is necessary to have an unambiguous marker for them. We have found that antibodies to the calcium-binding protein calretinin label Cajal-Retzius cells in the rat throughout the whole period of corticogenesis into adulthood. Calretinin positive cells were also detected in the subplate, cortical plate and the ventricular zone. Transient expression of calretinin was observed in cells of the infragranular layers of the developing cortex. We conclude that calretinin can be used as a marker protein for Cajal-Retzius cells.
为了能够研究在皮质发生过程中边缘区（预期的第I层）中仍存在争议的大 Cajal-Retzius 细胞的命运和功能，有必要为它们找到一种明确的标记物。我们发现，针对钙结合蛋白钙视网膜蛋白的抗体在大鼠整个皮质发生期直至成年期都能标记 Cajal-Retzius 细胞。在皮质下板、皮质板和脑室区也检测到了钙视网膜蛋白阳性细胞。在发育中的皮质颗粒下层的细胞中观察到了钙视网膜蛋白的短暂表达。我们得出结论，钙视网膜蛋白可作为 Cajal-Retzius 细胞的标记蛋白。
