Zhang W Q, Xu G S, Huang G W
Department of Nutrition and Food Hygiene Tianjin Medical College.
Zhonghua Yu Fang Yi Xue Za Zhi. 1994 May;28(3):158-61.
Twenty-one male rabbits were administered with alum (aluminum potassium sulfate) for 32 weeks to study the accumulative toxic effects of aluminum in food additives on central nervous system. Results showed aluminum levels in blood and brain tissue of the animals increased significantly with intake of alum (P < 0.01). Blood zinc levels, and activities of superoxide dismutase (SOD) and monoamine oxidase B (MAO-B) correlated negatively with aluminum levels in blood and brain, and SOD activity correlated negatively to accumulative aluminum deposit and positively to lipid oxide level in brain. Pathological examinations showed lesions in gyrus centralis anterior, gyrus hippocampi and spinal cord of the animals got more severely and extensively with aluminum intake and brain aluminum content, with disarrangement of neurofilaments and neurotubule, and deformation of synaptic structures.
给21只雄性兔子喂食明矾（硫酸铝钾）32周，以研究食品添加剂中的铝对中枢神经系统的累积毒性作用。结果显示，随着明矾摄入量的增加，动物血液和脑组织中的铝含量显著增加（P < 0.01）。血液锌水平、超氧化物歧化酶（SOD）和单胺氧化酶B（MAO-B）的活性与血液和大脑中的铝含量呈负相关，SOD活性与大脑中铝的累积沉积呈负相关，与脂质氧化物水平呈正相关。病理检查显示，随着铝摄入量和脑铝含量的增加，动物大脑中央前回、海马回和脊髓的病变更加严重和广泛，神经丝和神经微管排列紊乱，突触结构变形。
