Yang G, Gao Y T, Ji B T
Cancer Institute Zhejiang Medical University, Hangzhou.
Zhonghua Yu Fang Yi Xue Za Zhi. 1994 Jul;28(4):195-8.
A population-based case-control study was conducted in 726 incident cases with colorectal cancer and 1400 controls matched on age and sex in Shanghai, to explore the possible difference in associations between colorectal cancer and dietary fiber and calcium of various sources. The results showed reverse correlation between intake of vegetable fiber and ascending and descending colon cancer and rectal cancer, and between intake of fruit fiber and ascending colon cancer only. Dietary intake of calcium from animal sources could reduce the relative risk of ascending and descending colon cancer. These associations still existed after adjustment of the effects of the factors such as age, sex, intakes of total calorie, vitamin C, saturated fatty acid, etc. with logistic regression model, which indicated all of those variables were independent of other ones. Intake of dietary fiber from grains and calcium from plant sources had no significant protection from colorectal cancer. This study also showed the protective effects of dietary fiber and calcium on colorectal cancer not only correlated to their intake, but also closely to their sorts and sources.
在上海开展了一项基于人群的病例对照研究，研究对象为726例新发结直肠癌病例以及1400例年龄和性别匹配的对照，以探讨结直肠癌与不同来源膳食纤维和钙之间关联的可能差异。结果显示，蔬菜纤维摄入量与升结肠癌、降结肠癌及直肠癌之间呈负相关，水果纤维摄入量仅与升结肠癌呈负相关。动物性来源的膳食钙摄入可降低升结肠癌和降结肠癌的相对风险。在采用逻辑回归模型对年龄、性别、总热量、维生素C、饱和脂肪酸等因素的影响进行校正后，这些关联依然存在，这表明所有这些变量相互独立。谷物膳食纤维和植物性来源钙的摄入对结直肠癌无显著保护作用。该研究还表明，膳食纤维和钙对结直肠癌的保护作用不仅与其摄入量有关，还与其种类和来源密切相关。
