Chalumeau H P
Eur J Epidemiol. 1994 Aug;10(4):487-90. doi: 10.1007/BF01719684.
In the event of a major influenza epidemic, the availability of a potent and safe vaccine would be a major concern. The following presentation describes the main features of a flu vaccine manufacturing campaign: beginning with the supply of embryonated eggs, in which the flu viruses are cultivated, through the different steps of vaccine production - egg harvest, purification, inactivation, splitting - down to the final vaccine formulation and aseptic filling in the appropriate containers. In usual times, such a production cycle takes over 70 weeks. In an emergency situation, the manufacturers and the authorities would have to take innovative approaches to minimize such delays. This will inevitably translate into an enormous strain on all the players in such a project, from the egg suppliers to the organisers of the vaccine dispatching and administration. It will result in suboptimal yields and costs. However, facing a massive and urgent need of vaccine, both the authorities and the vaccine manufacturers must work together to supply the necessary doses in time.
在发生重大流感疫情时，一种有效且安全的疫苗的供应将成为主要关注点。以下介绍描述了流感疫苗生产活动的主要特征：从供应用于培养流感病毒的受精鸡蛋开始，历经疫苗生产的不同步骤——收获鸡蛋、纯化、灭活、裂解——直至最终的疫苗配方以及在合适容器中的无菌灌装。在正常时期，这样一个生产周期需要超过70周。在紧急情况下，制造商和当局将不得不采取创新方法以尽量减少此类延迟。这将不可避免地给该项目中的所有参与者带来巨大压力，从鸡蛋供应商到疫苗分发与管理的组织者。这将导致产量不理想和成本增加。然而，面对对疫苗的大量紧急需求，当局和疫苗制造商必须共同努力及时提供必要剂量的疫苗。
