Matinlauri I, Anttila L, Jaatinen T A, Koskinen P, Aalto M, Irjala K, Nikkanen V
University Central Hospital of Turku, Finland.
Fertil Steril. 1995 Feb;63(2):307-13. doi: 10.1016/s0015-0282(16)57361-0.
To examine the influence of polycystic ovarian disease (PCOD) on the levels of total renin in plasma and follicular fluid (FF) after stimulation with hMG.
Comparative study of the plasma and FF concentrations of total renin in women with and without PCOD after stimulation with hMG.
In vitro fertilization-embryo transfer program at the Department of Obstetrics and Gynecology, the University Central Hospital of Turku, Finland.
Thirty-six women undergoing IVF-ET for infertility with (n = 10) or without (n = 26) ultrasonographically diagnosed PCOD. Of the latter group, 15 women had tubal infertility, and the rest suffered from an anovulatory infertility and reacted with PCO-like ovarian response to stimulation.
The concentrations of total renin in plasma and FF, serum E2, and protein in FF.
The concentrations of plasma total renin after the gonadotropin stimulation were significantly higher in the PCOD and PCO-like groups when compared with the tubal group. The concentration of total renin in FF and the ratio of total renin per protein in FF were higher in the PCOD and PCO-like groups than in the tubal group, but the differences did not reach statistical significance. Positive correlations were found between the plasma total renin and serum E2 concentrations in the PCO-like and in the tubal group and between plasma total renin concentrations and the number of mature follicles in all groups. Follicular fluid total renin did not correlate with FF protein in any group. All findings were independent of the total hMG dosage used and the body mass index of the patients.
In the present study the concentrations of total renin in plasma were enhanced markedly after gonadotropin stimulation in women with PCOD compared with women having tubal infertility. The pattern of the hormonal secretions revealed a group of infertile patients reacting biochemically like women with PCOD.
研究多囊卵巢疾病（PCOD）对人绝经期促性腺激素（hMG）刺激后血浆及卵泡液（FF）中总肾素水平的影响。
对接受hMG刺激的患有和未患有PCOD的女性的血浆和FF中总肾素浓度进行比较研究。
芬兰图尔库大学中心医院妇产科的体外受精 - 胚胎移植项目。
36名因不孕接受体外受精 - 胚胎移植的女性，其中经超声诊断患有PCOD的10名（n = 10），未患PCOD的26名（n = 26）。后一组中，15名女性为输卵管性不孕，其余为无排卵性不孕且对刺激呈现多囊卵巢样（PCO样）卵巢反应。
血浆和FF中总肾素浓度、血清E2以及FF中的蛋白质。
与输卵管性不孕组相比，PCOD组和PCO样组在促性腺激素刺激后血浆总肾素浓度显著更高。PCOD组和PCO样组FF中总肾素浓度以及FF中总肾素与蛋白质的比值高于输卵管性不孕组，但差异未达到统计学意义。在PCO样组和输卵管性不孕组中，血浆总肾素与血清E2浓度之间以及在所有组中血浆总肾素浓度与成熟卵泡数量之间均发现正相关。在任何组中，卵泡液总肾素与FF蛋白质均无相关性。所有结果均独立于所用hMG的总剂量以及患者的体重指数。
在本研究中，与输卵管性不孕女性相比，PCOD女性在促性腺激素刺激后血浆中总肾素浓度显著升高。激素分泌模式显示出一组不孕患者在生化反应上类似于患有PCOD的女性。
