Yokosuka K, Teshima H, Yamakawa Y, Hasumi K
Department of Gynecology, Cancer Institute Hospital, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1994 Nov;46(11):1241-6.
The natural history and biological behavior of cystic glandular hyperplasia (CGH), which has been considered to be a precursor of endometrial carcinoma, still remain unclear. The present prospective study included 52 patients with CGH, who were followed up for 6 months to 5 years with occasional curettage, surgical procedures or hormonal therapy. The lesion disappeared in 35 cases (67.3%), persisted in 12 cases (23.1%) and became more serious in 5 cases (9.6%). Of these 5 cases, one case was found to have endometrial carcinoma during her follow-up. Nuclear DNA analysis was performed by Flow cytometry in 8 CGH cases. Eighty four point nine % of the cells from these 8 cases were in G0+1 phase, 8.3% in S phase and 7.4% in G2 + M phase. The proliferation index for CGH was 15.7%. Proliferative and mitotic activities of CGH were found to be similar to those of adenomatous hyperplasia, and the levels of these activities were between those of normal endometrium and atypical hyperplasia.G1.
囊性腺性增生（CGH）被认为是子宫内膜癌的前驱病变，但其自然病史和生物学行为仍不清楚。本前瞻性研究纳入了52例CGH患者，通过定期刮宫、手术或激素治疗对其进行了6个月至5年的随访。病变消失35例（67.3%），持续存在12例（23.1%），病情加重5例（9.6%）。在这5例病情加重的患者中，有1例在随访期间被发现患有子宫内膜癌。对8例CGH患者进行了流式细胞术核DNA分析。这8例患者中，84.9%的细胞处于G0+1期，8.3%处于S期，7.4%处于G2+M期。CGH的增殖指数为15.7%。发现CGH的增殖和有丝分裂活性与腺瘤样增生相似，且这些活性水平介于正常子宫内膜和非典型增生之间。G1。
