Wojnicki F H, Bacher J D, Glowa J R
Laboratory of Medicinal Chemistry, NIDDK, Bethesda, MD 20892.
Lab Anim Sci. 1994 Oct;44(5):491-4.
To investigate new approaches for treatment of drug abuse, subcutaneous vascular ports were implanted in rhesus monkeys (Macaca mulatta) for use in drug self-administration studies. Internal or external jugular veins were cannulated, and the catheter was attached to a subcutaneous port that was positioned on the back between the shoulder blades. This port/catheter system allowed easy serial blood sampling and intravenous drug administration. Daily use of the ports in awake monkeys was simple, effective, and caused no apparent stress over a 2-h experimental session. At the time of submission, the mean functional lifetime of the port/catheter system in 20 monkeys implanted longer than 6 months was 243.61 days, with the upper range being 540 days. Several complications developed with this system, and solutions to these problems are described. With proper aseptic use, the subcutaneous vascular port system provided a safe and enduring method for daily access for intravenous sampling and/or drug delivery. The duration of the preparation is a considerable improvement compared with exteriorized catheterization.
为了研究药物滥用的新治疗方法，在恒河猴（猕猴）体内植入皮下血管端口，用于药物自我给药研究。将颈内静脉或颈外静脉插管，导管连接到位于肩胛骨之间背部的皮下端口。这种端口/导管系统便于进行连续的血液采样和静脉内给药。在清醒的猴子中，每天使用该端口操作简单、有效，并且在2小时的实验过程中不会造成明显的压力。在提交本文时，20只植入时间超过6个月的猴子中，端口/导管系统的平均功能寿命为243.61天，上限为540天。该系统出现了一些并发症，并描述了这些问题的解决方案。通过适当的无菌操作，皮下血管端口系统为每日静脉采样和/或药物输送提供了一种安全且持久的方法。与外置导管插入术相比，准备时间有了显著改善。
