Teoh M K, Chong J M, Mohamed J, Phang K S
Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Med J Malaysia. 1994 Sep;49(3):255-62.
Antioxidants such as tocotrienols may protect against atherosclerosis since tissue injury from free radicals is a final common pathway of damage in arterial disease. In this study, the effects of tocotrienols on serum cholesterol, lipid peroxides, and aorta atheroma were assessed in rabbits fed an atherogenic diet for 12 weeks. Tocotrienols were more effective than tocopherols in preventing increases in serum LDL (p = 0.03) and total cholesterol (p = 0.008) levels in the cholesterol-fed rabbits. Elevation of serum lipid peroxides was effectively suppressed by tocotrienols (p = 0.01). Both tocopherols and tocotrienols offered significant protection against atheroma in the rabbit aorta, but tocotrienols had a stronger hypolipidaemic effect.
生育三烯酚等抗氧化剂可能预防动脉粥样硬化，因为自由基造成的组织损伤是动脉疾病损害的最终共同途径。在本研究中，对喂食致动脉粥样化饮食12周的兔子评估了生育三烯酚对血清胆固醇、脂质过氧化物和主动脉粥样瘤的影响。在喂食胆固醇的兔子中，生育三烯酚在预防血清低密度脂蛋白（LDL）升高（p = 0.03）和总胆固醇水平升高（p = 0.008）方面比生育酚更有效。生育三烯酚有效抑制了血清脂质过氧化物的升高（p = 0.01）。生育酚和生育三烯酚都对兔子主动脉粥样瘤提供了显著的保护作用，但生育三烯酚具有更强的降血脂作用。
