Sharma I, Gusain D, Dixit V P
Department of Zoology, University of Rajasthan, Jaipur.
Indian J Physiol Pharmacol. 1991 Jan;35(1):10-4.
Plumbagin (2-methyl-5-hydroxy, 1:4 naphthoquinone) isolated from the roots of Plumbago zeylanica when administered to hyperlipidaemic rabbits, reduced serum cholesterol and LDL-Chol. by 53 to 86 percent and 61 to 91 percent respectively. It lowered cholesterol/phospholipid ratio by 45.8 percent and elevates the decreased HDL-Chol significantly. Further, Plumbagin treatment prevented the accumulation of cholesterol and triglycerides in liver and aorta and regressed atheromatous plaques of thoracic and abdominal aorta. Plumbagin treated hyperlipidaemic subjects excreted more fecal cholesterol and phospholipids. In conclusion-Plumbagin feeding brings about a definite regression of atheroma and prevents the accumulation of cholesterol and triglycerides in liver and aorta.
从白花丹根中分离出的白花丹素（2-甲基-5-羟基，1:4萘醌）给予高脂血症兔子后，血清胆固醇和低密度脂蛋白胆固醇分别降低了53%至86%和61%至91%。它使胆固醇/磷脂比率降低了45.8%，并显著提高了降低的高密度脂蛋白胆固醇。此外，白花丹素治疗可防止肝脏和主动脉中胆固醇和甘油三酯的积累，并使胸主动脉和腹主动脉的动脉粥样斑块消退。接受白花丹素治疗的高脂血症受试者排出了更多的粪便胆固醇和磷脂。总之，喂食白花丹素可使动脉粥样硬化明显消退，并防止胆固醇和甘油三酯在肝脏和主动脉中积累。
