Morris C M, Candy J M, Kerwin J M, Edwardson J A
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.
Neuropathol Appl Neurobiol. 1994 Oct;20(5):473-7. doi: 10.1111/j.1365-2990.1994.tb00998.x.
Several lines of evidence suggest that aluminium may play a role in the pathogenesis of Alzheimer's disease (AD). The iron transport protein transferrin is the major transport protein for aluminium, and aluminium gains access to cells by means of a specific cell surface transferrin receptor. We have assessed the distribution of transferrin receptors in the normal and AD hippocampal formation using [3H]-transferrin ([3H]-Tf) binding and tritium film autoradiography, in order to assess the role of the transferrin receptor in AD. In normal brain, [3H]-Tf binding was highest in the pyramidal cell layers with CA2 > dentate gyrus granule cell layer > or = CA1 > CA3 > or = CA4 > subiculum > parahippocampal gyrus. In AD, significant reductions in [3H]-Tf binding were found in CA1, CA2 and CA4 pyramidal cell layers. The reduced [3H]-Tf binding in AD may, however, be due to poor pre-mortem agonal states which correlated with reduced [3H]-Tf binding. The discrepancy between the distribution of transferrin receptors in the hippocampus and those areas which are prone to the formation of senile plaques and neurofibrillary tangles suggests that if transferrin-mediated uptake of aluminium in AD/SDAT is significant in the pathogenesis of this disorder, it is not the only determinant of Alzheimer-type neuropathology.
多条证据表明铝可能在阿尔茨海默病（AD）的发病机制中起作用。铁转运蛋白转铁蛋白是铝的主要转运蛋白，铝通过特定的细胞表面转铁蛋白受体进入细胞。为了评估转铁蛋白受体在AD中的作用，我们使用[3H] - 转铁蛋白（[3H] - Tf）结合和氚胶片放射自显影技术评估了正常和AD海马结构中转铁蛋白受体的分布。在正常大脑中，[3H] - Tf结合在锥体细胞层中最高，CA2＞齿状回颗粒细胞层＞或 = CA1＞CA3＞或 = CA4＞海马下托＞海马旁回。在AD中，发现CA1、CA2和CA4锥体细胞层中[3H] - Tf结合显著减少。然而，AD中[3H] - Tf结合减少可能是由于死前濒死状态不佳，这与[3H] - Tf结合减少相关。海马中转铁蛋白受体的分布与那些易于形成老年斑和神经原纤维缠结的区域之间的差异表明，如果转铁蛋白介导的铝摄取在AD / SDAT发病机制中对该疾病的发病机制有显著影响，那么它不是阿尔茨海默型神经病理学的唯一决定因素。
