Morris C M, Candy J M, Omar S, Bloxham C A, Edwardson J A
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.
Neuropathol Appl Neurobiol. 1994 Oct;20(5):468-72. doi: 10.1111/j.1365-2990.1994.tb00997.x.
Several hypotheses have been put forward to explain the pathogenesis of Parkinson's disease (PD) and recently it has been suggested that alterations in iron homeostasis may be implicated. Because of the central role of the transferrin receptor in providing access of iron to cells, we have studied the distribution and density of transferrin receptors using [3H]-transferrin ([3H]-Tf) binding and tritium film autoradiography in the normal and PD midbrain. High levels of [3H]-Tf binding were found in the dorsal raphé, oculomotor nucleus and periaqueductal grey whilst lower levels of [3H]-Tf binding were found in the tegmentum, red nucleus and substantia nigra. Significant reductions in binding were found in the substantia nigra, red nucleus and oculomotor nucleus in PD, the reductions in [3H]-Tf binding being similar to the loss of nigral neurons in PD. The data suggest that the increased iron content of surviving nigral neurons may reflect a compensatory metabolic response rather than abnormal transferrin receptor expression.
已经提出了几种假说来解释帕金森病（PD）的发病机制，最近有人提出铁稳态的改变可能与之有关。由于转铁蛋白受体在为细胞提供铁的过程中起着核心作用，我们利用[3H] - 转铁蛋白（[3H] - Tf）结合和氚胶片放射自显影技术研究了正常和PD中脑中转铁蛋白受体的分布和密度。在背侧中缝核、动眼神经核和导水管周围灰质中发现了高水平的[3H] - Tf结合，而在被盖、红核和黑质中发现了较低水平的[3H] - Tf结合。在PD患者的黑质、红核和动眼神经核中发现结合显著减少，[3H] - Tf结合的减少与PD中黑质神经元的丧失相似。数据表明，存活的黑质神经元中铁含量的增加可能反映了一种代偿性代谢反应，而不是转铁蛋白受体表达异常。
