• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型受体样酪氨酸激酶DDR在人乳腺肿瘤中的表达模式

Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours.

作者信息

Barker K T, Martindale J E, Mitchell P J, Kamalati T, Page M J, Phippard D J, Dale T C, Gusterson B A, Crompton M R

机构信息

Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, UK.

出版信息

Oncogene. 1995 Feb 2;10(3):569-75.

PMID:7845682
Abstract

Using a reverse transcriptase-polymerase chain reaction based differential screening procedure, we have identified the discoidin domain receptor as a protein tyrosine kinase that is expressed in lymph nodes containing breast tumour metastases. By Northern blotting and in situ hybridisation we have demonstrated the expression of the discoidin domain receptor in human primary breast tumour samples, metastasis-containing lymph nodes and a number of normal tissues. Direct comparison of malignant breast and adjacent normal epithelial tissue revealed over expression in the tumour cells.

摘要

利用基于逆转录酶-聚合酶链反应的差异筛选程序，我们已将盘状结构域受体鉴定为一种蛋白酪氨酸激酶，它在含有乳腺肿瘤转移灶的淋巴结中表达。通过Northern印迹法和原位杂交，我们已证实盘状结构域受体在人类原发性乳腺肿瘤样本、含有转移灶的淋巴结及一些正常组织中均有表达。对恶性乳腺组织和相邻正常上皮组织的直接比较显示，该受体在肿瘤细胞中过度表达。

相似文献

1
Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours.新型受体样酪氨酸激酶DDR在人乳腺肿瘤中的表达模式
Oncogene. 1995 Feb 2;10(3):569-75.
2
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.非小细胞肺癌中盘状结构域受体1和2的表达及突变分析
Br J Cancer. 2007 Mar 12;96(5):808-14. doi: 10.1038/sj.bjc.6603614. Epub 2007 Feb 13.
3
The genomic structure of discoidin receptor tyrosine kinase.盘状结构域受体酪氨酸激酶的基因组结构。
Genome Res. 1996 Jul;6(7):620-7. doi: 10.1101/gr.6.7.620.
4
Overexpression of protein tyrosine kinases in human esophageal cancer.蛋白酪氨酸激酶在人食管癌中的过表达。
Pathobiology. 1997;65(4):195-203. doi: 10.1159/000164123.
5
Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.
Cell Growth Differ. 1994 Nov;5(11):1173-83.
6
Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland.松弛素样因子（RLF）在正常和肿瘤性人类乳腺组织中存在差异表达。
Cancer. 2000 Dec 1;89(11):2161-8.
7
Hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and their receptors in human breast cells and tissues: alternative receptors.肝细胞生长因子（HGF）、角质形成细胞生长因子（KGF）及其在人乳腺细胞和组织中的受体：替代受体
Cell Mol Biol Res. 1994;40(4):337-50.
8
Structure and expression of the Tyro 10 receptor tyrosine kinase.酪氨酸激酶10受体酪氨酸激酶的结构与表达
Oncogene. 1994 Mar;9(3):877-83.
9
Overexpression of the G-protein inwardly rectifying potassium channel 1 (GIRK1) in primary breast carcinomas correlates with axillary lymph node metastasis.原发性乳腺癌中G蛋白内向整流钾通道1（GIRK1）的过表达与腋窝淋巴结转移相关。
Cancer Res. 2001 Jan 15;61(2):582-8.
10
Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients.DDR2 表达增加：乳腺癌患者预后不良的新的独立预后标志物。
Med Oncol. 2013 Mar;30(1):397. doi: 10.1007/s12032-012-0397-3. Epub 2013 Jan 10.

引用本文的文献

1
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.泛素特异性蛋白酶7介导的盘状结构域受体1的稳定促进TP53突变型癌症的进展。
J Biol Chem. 2025 Jul 24;301(9):110515. doi: 10.1016/j.jbc.2025.110515.
2
Codon Bias of the Gene and Transcription Factor EHF in Multiple Species.多个物种中基因和转录因子 EHF 的密码子偏好性。
Int J Mol Sci. 2024 Oct 4;25(19):10696. doi: 10.3390/ijms251910696.
3
Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma.
盘状结构域受体1（DDR1）抑制和敲除后调节性T细胞浸润改变促进肺腺癌肿瘤生长
Cancers (Basel). 2023 Dec 8;15(24):5767. doi: 10.3390/cancers15245767.
4
Focusing on discoidin domain receptors in premalignant and malignant liver diseases.关注癌前和恶性肝脏疾病中的盘状结构域受体。
Front Oncol. 2023 Mar 15;13:1123638. doi: 10.3389/fonc.2023.1123638. eCollection 2023.
5
Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer.盘状结构域受体酪氨酸激酶1和盘状结构域受体酪氨酸激酶2在乳腺癌和卵巢癌中作用的最新进展
Front Cell Dev Biol. 2021 Nov 3;9:747314. doi: 10.3389/fcell.2021.747314. eCollection 2021.
6
The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.DDR1 和 DDR2 激酶抑制剂作为抗癌领域的后起之秀的发展历程。
Int J Mol Sci. 2021 Jun 18;22(12):6535. doi: 10.3390/ijms22126535.
7
Extracellular matrix and its therapeutic potential for cancer treatment.细胞外基质及其在癌症治疗中的治疗潜力。
Signal Transduct Target Ther. 2021 Apr 23;6(1):153. doi: 10.1038/s41392-021-00544-0.
8
Targeting the Extra-Cellular Matrix-Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors.靶向细胞外基质-肿瘤细胞串扰进行抗癌治疗：整合素抑制剂的新兴替代方案
Front Oncol. 2020 Jul 22;10:1231. doi: 10.3389/fonc.2020.01231. eCollection 2020.
9
Design and Optimization of 3'-(Imidazo[1,2-]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors.3'-(咪唑并[1,2 -]吡嗪 - 3 - 基)-[1,1'-联苯]-3 - 羧酰胺作为选择性DDR1抑制剂的设计与优化
ACS Med Chem Lett. 2020 Jan 6;11(3):379-384. doi: 10.1021/acsmedchemlett.9b00495. eCollection 2020 Mar 12.
10
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy.靶向 DDR2 可增强肿瘤对抗 PD-1 免疫治疗的反应。
Sci Adv. 2019 Feb 20;5(2):eaav2437. doi: 10.1126/sciadv.aav2437. eCollection 2019 Feb.