State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Changle Western Road, Xi'an, Shaanxi 710032, People's Republic of China.
Med Oncol. 2013 Mar;30(1):397. doi: 10.1007/s12032-012-0397-3. Epub 2013 Jan 10.
The discoidin domain receptors, DDR1 and DDR2, have been linked with numerous human cancers. We sought to determine expression level and distribution of DDRs in human breast cancer, and investigate prognostic determinates to determine whether levels of DDRs could predict survival. Tumor samples from 122 breast cancer patients were analyzed for relative expression of DDRs. An additional 24 matched tumor and normal tissues were tested for differential expression of DDR1 and DDR2. DDR2 was found to be significantly increased by 6-fold (P = 0.0005) and DDR1 decreased (P = 0.0001) in tumor vs. normal breast tissue. DDR1 expression was not predictive for patient survival; however, DDR2 expression was significantly associated with disease-free (HR = 0.55, 95 % CI = 0.24-0.78, P = 0.026) and overall survival (HR = 0.46, 95 % CI = 0.35-0.84, P = 0.019). Multivariate analysis revealed DDR2 is an independent favorable predictor for prognosis independent of tumor stage, histology, and patient age. The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome.
盘状结构域受体 DDR1 和 DDR2 与多种人类癌症有关。我们试图确定 DDR 在人乳腺癌中的表达水平和分布，并研究预后决定因素，以确定 DDR 水平是否可以预测生存。分析了 122 例乳腺癌患者肿瘤样本中 DDRs 的相对表达。另外 24 对匹配的肿瘤和正常组织用于检测 DDR1 和 DDR2 的差异表达。与正常乳腺组织相比，肿瘤中 DDR2 的表达显著增加了 6 倍（P = 0.0005），而 DDR1 则降低（P = 0.0001）。DDR1 的表达不能预测患者的生存；然而，DDR2 的表达与无病（HR = 0.55，95 % CI = 0.24-0.78，P = 0.026）和总生存（HR = 0.46，95 % CI = 0.35-0.84，P = 0.019）显著相关。多变量分析显示，DDR2 是独立于肿瘤分期、组织学和患者年龄的预后的独立有利预测因子。本研究首次提供了证据表明，原发性人乳腺癌中 DDR2 mRNA 表达的增加可能是复发和预后的强大独立预测因子。
