Forgie I M, O'Neill K P, Lloyd-Evans N, Leinonen M, Campbell H, Whittle H C, Greenwood B M
Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
Pediatr Infect Dis J. 1991 Jan;10(1):42-7. doi: 10.1097/00006454-199101000-00009.
Seventy-four children ages 1 to 9 years hospitalized because of severe pneumonia were investigated using blood cultures, lung aspirates, nasopharyngeal aspirates, serology and antigen detection procedures. A bacterial infection was identified in 57 (77%), a viral infection was seen in 25 (34%) and 18 (24%) had mixed viral-bacterial infections. The bacterial pathogens most frequently identified were Streptococcus pneumoniae and Haemophilus influenzae found in 61 and 15% of patients, respectively. The viral pathogen most frequently recovered was respiratory syncytial virus (12%). Evidence of Chlamydia pneumoniae strain TWAR and Mycoplasma pneumoniae infection was found in 12 and 4% of cases, respectively. Overall a potential pathogen was identified in 60 (81%) children, with evidence of polymicrobial infection in 30 cases (40.5%). The study provides information on the relative role of different infectious agents in the etiology of severe pneumonia in children in a developing country.
对74名因重症肺炎住院的1至9岁儿童进行了调查，采用了血培养、肺穿刺抽吸物、鼻咽抽吸物、血清学和抗原检测方法。57例（77%）确诊为细菌感染，25例（34%）为病毒感染，18例（24%）为病毒 - 细菌混合感染。最常鉴定出的细菌病原体是肺炎链球菌和流感嗜血杆菌，分别在61%和15%的患者中发现。最常检出的病毒病原体是呼吸道合胞病毒（12%）。肺炎衣原体TWAR株和肺炎支原体感染的证据分别在12%和4%的病例中发现。总体而言，60例（81%）儿童中鉴定出潜在病原体，30例（40.5%）有多重微生物感染的证据。该研究提供了关于不同感染因子在一个发展中国家儿童重症肺炎病因中相对作用的信息。
