Yasue M, Sakamoto J, Teramukai S, Morimoto T, Yasui K, Kuno N, Kurimoto K, Ohashi Y
Department of Surgery, Aichi Prefectural Hospital, Okazaki, Japan.
Pancreas. 1994 Nov;9(6):735-40. doi: 10.1097/00006676-199411000-00011.
Preoperative serum levels of carcinoembryonic antigen (CEA) and/or carbohydrate antigen 19.9 (CA19.9) were measured in 90 patients with advanced pancreatic cancer. CEA antigen was above the cutoff levels of 5.0 ng/ml in 51% of patients and CA19.9 was above the cutoff limit of 37 U/ml in 87% of patients. High preoperative CEA and CA19.9 levels were related to a poor prognosis of the patients. In multivariate analysis, the hazard rate was significantly higher in the high-CEA group (> 2.5 ng/ml) compared to the low-CEA group (< 2.4 ng/ml). An increase in CEA and/or CA19.9 within 1 month after the operation was also significantly related to the hazard rate. This study reconfirms the prognostic importance of preoperative and postoperative CEA and CA19.9.
对90例晚期胰腺癌患者术前测定癌胚抗原（CEA）和/或糖类抗原19.9（CA19.9）的血清水平。51%的患者CEA抗原高于5.0 ng/ml的临界值，87%的患者CA19.9高于37 U/ml的临界值。术前CEA和CA19.9水平高与患者预后不良相关。在多变量分析中，高CEA组（>2.5 ng/ml）的风险率显著高于低CEA组（<2.4 ng/ml）。术后1个月内CEA和/或CA19.9升高也与风险率显著相关。本研究再次证实术前和术后CEA及CA19.9对预后的重要性。
