Förstl H, Besthorn C, Burns A, Geiger-Kabisch C, Levy R, Sattel A
Central Institute of Mental Health, Mannheim, Germany.
Psychopathology. 1994;27(3-5):194-9. doi: 10.1159/000284869.
Delusional misidentification symptoms (DMS) are common in Alzheimer's disease (AD) and they are frequent sources of serious distress for patients and particularly caregivers. We observed DMS in around 30% of the patients with moderate to severe AD in two independent prospective studies; the Capgras type, phantom boarder, mirror and TV DMS were found most frequently. Patients with DMS showed increased EEG delta-power over the right hemisphere, their CT scans showed more severe right frontal lobe atrophy, and the number of their pyramidal cells in area CA1 was lower than in the patients without DMS. This may indicate that the development of DMS in AD can be promoted by certain patterns of brain degeneration which affect systems relevant to the recognition and updating of memories, while verbal skills may initially be left largely intact.
妄想性错认症状（DMS）在阿尔茨海默病（AD）中很常见，是患者尤其是护理人员严重痛苦的常见来源。在两项独立的前瞻性研究中，我们在约30%的中重度AD患者中观察到了DMS；最常发现的是卡普格拉型、幻影边界、镜像和电视DMS。患有DMS的患者右半球脑电图δ波功率增加，其CT扫描显示右额叶萎缩更严重，海马体CA1区的锥体细胞数量低于没有DMS的患者。这可能表明，AD中DMS的发展可由某些影响与记忆识别和更新相关系统的脑退化模式所促进，而语言技能最初可能在很大程度上保持完好。
