Layfield L J, Wax T D, Lee J G, Cotton P B
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Acta Cytol. 1995 Jan-Feb;39(1):11-8.
One hundred eight brushing cytology specimens with adequate follow-up were obtained from strictures of the biliary and pancreatic ducts. The material was classified as benign, reactive, low grade dysplasia, high grade dysplasia or adenocarcinoma. A diagnosis of carcinoma was made in 18 patients, high grade dysplasia in 12, low grade dysplasia in 6 and benign, nonneoplastic in the remaining cases. The diagnostic sensitivity for carcinoma was 44%, with a specificity of 98%. Ten of 12 patients with high grade dysplasia demonstrated other evidence of carcinoma. No complications were encountered. Brushing cytodiagnosis of extrahepatic biliary and pancreatic duct strictures appears to be a safe procedure, with high specificity but only modest sensitivity.
从胆管和胰管狭窄处获取了108份有充分随访资料的刷片细胞学标本。材料被分类为良性、反应性、低级别发育异常、高级别发育异常或腺癌。18例患者诊断为癌，12例为高级别发育异常，6例为低级别发育异常，其余病例为良性、非肿瘤性。癌的诊断敏感性为44%，特异性为98%。12例高级别发育异常患者中有10例显示出癌的其他证据。未遇到并发症。肝外胆管和胰管狭窄的刷片细胞诊断似乎是一种安全的检查方法，特异性高但敏感性一般。
