Cochran E J, Fox J H, Mufson E J
Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Acta Neuropathol. 1994;88(5):479-84. doi: 10.1007/BF00389503.
We report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Pick's disease pathology, as well as extensive paired helical filament -- immunoreactive neurities, with few Alzheimer's disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal complex. In addition, synaptophysin immunostaining of the hippocampal complex showed a bilaminar pattern of immunoreactivity in the outer molecular layer as previously described in AD.
我们报告了一例69岁女性患者，其患有11年的进行性痴呆病史，尸检发现有典型的皮克病病理特征，以及广泛的双螺旋丝免疫反应性神经突，仅有少量阿尔茨海默病（AD）样神经原纤维缠结且无老年斑。皮克小体和神经突变性在新皮质和海马复合体中均广泛存在。此外，海马复合体的突触素免疫染色显示，在外分子层有双层免疫反应模式，这与先前在AD中所描述的情况相同。
