Quintero R A, Hume R, Smith C, Johnson M P, Cotton D B, Romero R, Evans M I
Center for Fetal Diagnosis and Therapy, Fetal Endoscopy Program, Hutzel Hospital, Detroit, MI.
Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):206-9. doi: 10.1016/0002-9378(95)90115-9.
Percutaneous fetal cystoscopy was performed in a male fetus with ultrasonographic evidence of lower urinary tract obstruction at 19 weeks of gestation. The diagnosis of posterior urethral valves was confirmed. Percutaneous endoscopic fulguration of the valves was successfully performed at 22 weeks of gestation, and urethral patency was established. This case illustrates the feasibility of performing diagnostic and therapeutic endoscopic procedures within the human fetus for the management of a congenital anomaly. While we believe that fetal cystoscopy may improve our diagnostic, prognostic, and therapeutic capabilities in the management of fetuses with lower obstructive uropathy, studies are needed to establish the actual value, risks, and limitations of this new approach in fetal medicine.
在一名妊娠19周的男性胎儿身上进行了经皮胎儿膀胱镜检查,超声检查显示该胎儿存在下尿路梗阻。后尿道瓣膜的诊断得到证实。在妊娠22周时成功进行了经皮内镜下瓣膜电灼术,并建立了尿道通畅。该病例说明了在人类胎儿体内进行诊断和治疗性内镜手术以处理先天性异常的可行性。虽然我们认为胎儿膀胱镜检查可能会提高我们对下尿路梗阻性肾病胎儿的诊断、预后评估和治疗能力,但仍需要开展研究以确定这种胎儿医学新方法的实际价值、风险和局限性。