Gabel S, Stadler J, Bjorn J, Shindledecker R, Bowden C L
Department of Psychiatry and Behavioral Sciences, Children's Hospital, Denver, CO 80218-1088.
Alcohol Clin Exp Res. 1994 Oct;18(5):1137-42. doi: 10.1111/j.1530-0277.1994.tb00094.x.
Both dopaminergic dysregulation and abnormalities in monoamine oxidase (MAO) have been postulated as etiological factors in substance abuse. This study assessed whether MAO activity differed in sons of substance-abusing fathers compared with sons of nonsubstance-abusing fathers. It also assessed the levels of homovanillic acid (HVA), the metabolite of dopamine, and MAO in a group of substance-using/-abusing boys compared with peers without this history in the same setting. Sixty-five boys admitted to a residential center were evaluated on blood tests for HVA and MAO, and on a series of diagnostic instruments and questionnaires designed to elicit information about parental substance abuse and about the subject's own substance use/abuse. The results indicated tentatively that younger (< 12.0 years) sons of substance-abusing fathers had higher levels of MAO than younger sons of nonsubstance-abusing fathers. Levels of MAO in older (> or = 12.0 years) sons of substance-abusing and nonsubstance-abusing fathers did not differ. Boys with histories of significant use/abuse of substances themselves had significantly higher MAO levels and significantly lower HVA levels than peers of the same age without substance use/abuse histories.
多巴胺能调节异常和单胺氧化酶（MAO）异常均被假定为物质滥用的病因学因素。本研究评估了与非物质滥用父亲的儿子相比，物质滥用父亲的儿子的MAO活性是否存在差异。该研究还评估了一组有物质使用/滥用经历的男孩与同一环境中无此经历的同龄人相比，多巴胺代谢产物高香草酸（HVA）和MAO的水平。对入住住宿中心的65名男孩进行了血液HVA和MAO检测，并使用一系列诊断工具和问卷来获取有关父母物质滥用以及受试者自身物质使用/滥用情况的信息。结果初步表明，物质滥用父亲的年幼（<12.0岁）儿子的MAO水平高于非物质滥用父亲的年幼儿子。物质滥用和非物质滥用父亲的年长（≥12.0岁）儿子的MAO水平没有差异。有大量物质使用/滥用史的男孩，其MAO水平显著高于且HVA水平显著低于无物质使用/滥用史的同龄同龄人。
