Bräuniger S, Fischer I, Peters J
Robert Koch-Institut, Bundesgesundheitsamtes, Berlin.
Zentralbl Hyg Umweltmed. 1994 Oct;196(3):270-8.
The stability of the bovine Parvovirus, strain Haden against moist heat in the temperature range 75 to 90 degrees C was tested. It was found that the resistance depended largely on the medium (distilled water, water of standardized hardness (WSH), plasm) in which the viruses were suspended during heating. In WSH the resistance was highest. When heated in plasm, the viruses were inactivated in two phases. From the temperature dependence of the D-values, z-values of 5,6 for distilled water and 8,2 for WSH were found. It is recommended to use the Parvovirus for the evaluation of chemo-thermic and thermic disinfection procedures in view of virucidal effectiveness. The usual pasteurizing procedures fail to inactivate the Parvovirus. To eliminate Parvoviruses from blood products, other methods are, therefore, necessary.
对牛细小病毒哈登株在75至90摄氏度温度范围内对湿热的稳定性进行了测试。结果发现，抵抗力在很大程度上取决于加热过程中病毒悬浮其中的介质（蒸馏水、标准硬度水（WSH）、血浆）。在WSH中抵抗力最高。在血浆中加热时，病毒分两个阶段失活。根据D值的温度依赖性，发现蒸馏水的z值为5.6，WSH的z值为8.2。鉴于其杀病毒效果，建议使用细小病毒来评估化学热和热消毒程序。通常的巴氏消毒程序无法使细小病毒失活。因此，要从血液制品中消除细小病毒，需要其他方法。
