Le Grand R, Clayette P, Noack O, Vaslin B, Theodoro F, Michel G, Roques P, Dormont D
Laboratoire de Neuropathologie Expérimentale et Neurovirologie, Centre de Recherches du Service de Santé des Armèes, Fontenay-aux-Roses, France.
AIDS Res Hum Retroviruses. 1994 Oct;10(10):1279-87. doi: 10.1089/aid.1994.10.1279.
We analyzed the kinetics of the virological and immunological events that occurred in four AZT-treated cynomolgus macaques during the acute infection that followed their exposure to the simian immunodeficiency virus (SIVmac251) grown on monkey PBMCs in a cell-free stock solution. These events included changes in the CD4+ and CD8+ T lymphocyte subsets, p27 antigenemia, infectious serum virus, and cell-associated virus loads. The kinetics of these changes proved strikingly similar to those reported in human HIV-1 infection. Four other SIV-exposed macaques were treated with placebo instead of AZT. We demonstrated that AZT does not prevent SIV infection, even when administered before SIV inoculation. However, the peaks of p27 antigenemia and of serum and cellular viremia were significantly smaller and occurred significantly later in the monkeys given AZT than in those given placebo.
我们分析了四只接受齐多夫定（AZT）治疗的食蟹猴在暴露于用无细胞储备溶液培养于猴外周血单核细胞（PBMC）上的猿猴免疫缺陷病毒（SIVmac251）后急性感染期间发生的病毒学和免疫学事件的动力学。这些事件包括CD4⁺和CD8⁺T淋巴细胞亚群的变化、p27抗原血症、传染性血清病毒以及细胞相关病毒载量。这些变化的动力学结果与人类HIV - 1感染中报道的结果惊人地相似。另外四只暴露于SIV的食蟹猴接受了安慰剂而非AZT治疗。我们证明，即使在接种SIV之前给药，AZT也不能预防SIV感染。然而，接受AZT治疗的猴子中p27抗原血症以及血清和细胞病毒血症的峰值明显较小，且出现的时间明显晚于接受安慰剂治疗的猴子。
