Smith S M, Makuwa M, Lee F, Gettie A, Russo C, Marx P A
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.
J Med Primatol. 1998 Apr-Jun;27(2-3):94-8. doi: 10.1111/j.1600-0684.1998.tb00232.x.
In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red-Capped Mangabey (RCM) in Gabon. SIVrcm is divergent from HIV-1 and HIV-2/SIV families of primate lentiviruses. In this report, additional in vitro replication studies and the results of SIVrcm infection in macaques are presented. SIVrcm causes little cytopathic effedct in Molt 4 Clone 8 cells and in rhesus and human PBMCs. In vivo, SIVrcm is non-pathogenic after 200 days in rhesus macaques and after one year in cynomolgous macaques, but does cause a chronic infection in both macaques.
