Coy D L, Howard J
Department of Physiology and Biophysics, University of Washington, Seattle 98195.
Curr Opin Neurobiol. 1994 Oct;4(5):662-7. doi: 10.1016/0959-4388(94)90007-8.
Recent advances of the past year in the field of organelle transport have documented the existence of numerous kinesin-related proteins and the presence of multiple conventional kinesins within neurons. Biochemical and genetic mutant analyses indicate that different kinesin superfamily members transport different organelles. In addition to microtubule-based systems, actin filaments and myosin motors are associated with organelle transport in axons. The great diversity of motor proteins suggests that they may play a role in sorting, in addition to transport.
过去一年里，细胞器运输领域的最新进展证明了众多驱动蛋白相关蛋白的存在以及神经元内多种传统驱动蛋白的存在。生化和遗传突变分析表明，不同的驱动蛋白超家族成员运输不同的细胞器。除了基于微管的系统外，肌动蛋白丝和肌球蛋白马达也与轴突中的细胞器运输相关。驱动蛋白的巨大多样性表明，它们除了运输作用外，可能还在分选过程中发挥作用。
