Henderson R C, Hayes P R
University of North Carolina, Chapel Hill 27599-7055.
Bone Miner. 1994 Oct;27(1):1-12. doi: 10.1016/s0169-6009(08)80181-x.
To evaluate the correlation between dietary calcium intake and mineralization of the immature skeleton 55 children and adolescents aged 5-14 years (mean, 9.5 years) with a positive radioallergosorbent test (RAST) for serum antibodies to cow's milk protein were evaluated. Bone mineral density (BMD) in the lumbar spine and proximal femurs were measured by dual energy X-ray absorptiometry. BMD at each site for each subject was converted to an age-adjusted Z score based on our own series of 95 normal pediatric controls. Calcium intake was determined using a detailed food frequency questionnaire administered by a nutritionist during a 30-40-min interview. Dietary adjustments to the condition varied and resulted in a wide range of calcium intakes. Calcium supplements were taken by 22% of the subjects and were included in the determination of daily calcium intake. The group of 55 subjects was divided into quartiles based on calcium intake (mean +/- S.E mg calcium/day): Group 1, 409 +/- 21, Group 2, 663 +/- 16, Group 3, 950 +/- 32, Group 4, 1437 +/- 124. Bone density Z scores in the proximal femur serially increased across the calcium intake groups (mean +/- S.E.): Group 1, -0.16 +/- 0.31; Group 2, 0.05 +/- 0.33; Group 3, 0.44 +/- 0.24; Group 4, 0.79 +/- 0.41 (P = 0.03). A similar pattern was found with lumbar spine BMD Z scores: Group 1, -0.16 +/- 0.27; Group 2, 0.10 +/- 0.21; Group 3, 0.18 +/- 0.20; Group 4, 0.30 +/- 0.25 (P = 0.05). These data add further to the evidence that dietary calcium intake is important for optimal mineralization of the growing skeleton.
为评估膳食钙摄入量与未成熟骨骼矿化之间的相关性，我们对55名5至14岁（平均9.5岁）血清牛奶蛋白抗体放射性变应原吸附试验（RAST）呈阳性的儿童和青少年进行了评估。采用双能X线吸收法测量腰椎和股骨近端的骨密度（BMD）。根据我们自己的95名正常儿科对照系列，将每个受试者每个部位的BMD转换为年龄校正Z评分。通过营养师在30 - 40分钟访谈期间使用详细的食物频率问卷来确定钙摄入量。针对该情况的饮食调整各不相同，导致钙摄入量范围广泛。22%的受试者服用了钙补充剂，并将其纳入每日钙摄入量的测定中。根据钙摄入量（平均±标准误，毫克钙/天）将55名受试者分为四分位数：第1组，409±21；第2组，663±16；第3组，950±32；第4组，1437±124。股骨近端的骨密度Z评分在各钙摄入量组中呈连续增加趋势（平均±标准误）：第1组，-0.16±0.31；第2组，0.05±0.33；第3组，0.44±0.24；第4组，0.79±0.41（P = 0.03）。腰椎BMD Z评分也发现了类似模式：第1组，-0.16±0.27；第2组，0.10±0.21；第3组，0.18±0.20；第4组，0.3±0.25（P = = 0.05）。这些数据进一步证明了膳食钙摄入量对生长中骨骼的最佳矿化很重要。
