Kröger H, Alhava E, Honkanen R, Tuppurainen M, Saarikoski S
Department of Surgery, Kuopio University Hospital, Finland.
Bone Miner. 1994 Oct;27(1):33-41. doi: 10.1016/s0169-6009(08)80184-5.
Bone mineral density (BMD) of the spine and femoral neck was measured in a random stratified sample of 3222 perimenopausal women aged 47-59 years. A total of 969 women had used fluoridated drinking water (1.0-1.2 mg/l) for over 10 years. These women were compared with 2253 women with low levels of fluoride in drinking water (< 0.3 mg/l). BMD of the spine was significantly higher in the fluoride group than in the non-fluoride group (1.138 +/- 0.165 vs. 1.123 +/- 0.156 g/cm2, P = 0.026). Femoral neck BMDs did not differ between the groups. When the BMD values were adjusted for confounding factors (age, weight, menopausal status, calcium intake, physical activity level, deliveries, alcohol consumption and estrogen use), the differences between the groups increased (P < 0.001 for the spine and P = 0.004 for the femoral neck, respectively). There was no significant difference between the groups in the prevalence of self-reported fractures sustained during 1980-1989. We propose that the fluoridation of drinking water has a slight increasing effect on axial BMD in women in low fluoride areas.
在一个由3222名年龄在47至59岁之间的围绝经期女性组成的随机分层样本中，测量了她们脊柱和股骨颈的骨矿物质密度（BMD）。共有969名女性饮用含氟饮用水（1.0 - 1.2毫克/升）超过10年。将这些女性与2253名饮用水中氟含量低（< 0.3毫克/升）的女性进行比较。氟组的脊柱骨密度显著高于非氟组（1.138 ± 0.165对1.123 ± 0.156克/平方厘米，P = 0.026）。两组之间股骨颈骨密度没有差异。当对骨密度值进行混杂因素（年龄、体重、绝经状态、钙摄入量、身体活动水平、分娩次数、饮酒量和雌激素使用情况）调整后，两组之间的差异增大（脊柱差异P < 0.001，股骨颈差异P = 0.004）。在1980 - 1989年期间自我报告的骨折发生率方面，两组之间没有显著差异。我们认为，在低氟地区，饮用水加氟对女性的轴向骨密度有轻微的增加作用。
