Wani J H, Srivastava V M
Dept. of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104.
Biochem Mol Biol Int. 1994 Sep;34(2):239-50.
The enzymes involved in the catabolism of malate namely fumarate reductase, NADH oxidase, "malic" enzyme, succinate dehydrogenase and fumarase as well as NADPH:NAD transhydrogenase, which is involved in the electron transport chain, were studied in Hymenolepis diminuta, a rat intestinal tapeworm. Among cations, K+ had no effect on any enzyme whereas Ca2+ and Mg2+ showed an increase or decrease of varying degrees of different enzyme activities. Most of the compounds, which have been synthesized by the Central Drug Research Institute, Lucknow (India) and found to possess some anthelmintic properties, strongly inhibited the above enzymes except malic enzyme.
在微小膜壳绦虫（一种大鼠肠道绦虫）中，研究了参与苹果酸分解代谢的酶，即延胡索酸还原酶、NADH氧化酶、“苹果酸”酶、琥珀酸脱氢酶和延胡索酸酶，以及参与电子传递链的NADPH:NAD转氢酶。在阳离子中，K+对任何酶都没有影响，而Ca2+和Mg2+对不同酶的活性有不同程度的增强或抑制作用。印度勒克瑙中央药物研究所合成的、具有一定驱虫特性的大多数化合物，除苹果酸酶外，均强烈抑制上述酶。
