神经胶质金属硫蛋白

Glial metallothionein.

作者信息

Young J K

机构信息

Department of Anatomy, Howard University, Washington, D.C. 20059.

出版信息

Biol Signals. 1994 May-Jun;3(3):169-75. doi: 10.1159/000109540.

DOI:10.1159/000109540

PMID:7849804

Abstract

The metal-binding protein, metallothionein (MT) has been found to be primarily produced by astrocytes in the rat and human brain. This review discusses the relationship of glial MT to the distribution of metals in the brain, possible roles of MT in the regulation of glial enzymes and other glial proteins, and the possible role of a subset of MT-immunoreactive glia, the Gomori-positive astrocytes, in defending against toxic metals that enter the brain via circumventricular organs. The possible involvement of MT-containing astrocytes in degenerative brain disorders in also briefly discussed.

摘要

金属结合蛋白，即金属硫蛋白（MT），已被发现在大鼠和人类大脑中主要由星形胶质细胞产生。本综述讨论了神经胶质MT与大脑中金属分布的关系、MT在调节神经胶质酶和其他神经胶质蛋白中的可能作用，以及MT免疫反应性神经胶质细胞的一个子集，即戈莫里阳性星形胶质细胞，在抵御通过室周器官进入大脑的有毒金属方面的可能作用。还简要讨论了含MT的星形胶质细胞在退行性脑疾病中的可能参与情况。