Angus J A
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
Curr Opin Nephrol Hypertens. 1994 Jan;3(1):99-106. doi: 10.1097/00041552-199401000-00014.
Vascular remodeling is a general term describing any change in blood vessel structure caused by hemodynamic changes, such as flow and pressure, injury, or disease. It also encompasses development and vascularity. This review focuses on the implications of remodeling from both structure and function of isolated arteries and on how a remodeled vascular bed responds to vasoactive stimuli. Essential, genetic, experimental, and pulmonary hypertension, endothelial dysfunction in atheroma, vascular surgery, subarachnoid hemorrhage, congestive heart failure, coronary collateralization, ischemia, and pregnancy are among the examples discussed in this review. Research efforts should be directed toward understanding the processes of cell-cell interaction underpinning these changes in structure and function. Much could be gained from better measurement of vascular structure and full stimulus-reactivity relationships under in vivo conditions in a variety of vascular beds and models of animal and human hypertension. Mathematical models of the average vascular structure drawn from experimental data aid clear thinking when discussing the remodeling process.
血管重塑是一个通用术语，描述由血流动力学变化（如流量和压力）、损伤或疾病引起的血管结构的任何变化。它还包括血管发育和血管形成。本综述重点关注孤立动脉结构和功能重塑的影响，以及重塑的血管床对血管活性刺激的反应。原发性、遗传性、实验性和肺动脉高压、动脉粥样硬化中的内皮功能障碍、血管手术、蛛网膜下腔出血、充血性心力衰竭、冠状动脉侧支循环、缺血和妊娠都是本综述中讨论的例子。研究工作应致力于理解支撑这些结构和功能变化的细胞间相互作用过程。通过在各种血管床以及动物和人类高血压模型的体内条件下更好地测量血管结构和完整的刺激 - 反应关系，可以获得很多收获。从实验数据得出的平均血管结构的数学模型有助于在讨论重塑过程时进行清晰的思考。
