Ambühl P, Felix D, Khosla M C
Division of Neurobiology, University of Berne, Switzerland.
Brain Res Bull. 1994;35(4):289-91. doi: 10.1016/0361-9230(94)90103-1.
Microiontophoretic application of both, the octapeptide angiotensin II (Ang II) and its N-terminal heptapeptide angiotensin-(1-7), [Ang-(1-7)], has been shown to increase the firing rate of rat hypothalamic paraventricular neurones. In the present microiontophoretic study, the effect of the angiotensin analogue [7-D-Ala]-Ang-(1-7) on Ang II- and Ang-(1-7)-induced firing rate increase of paraventricular neurones has been tested. While the response to Ang II was unchanged, the response to Ang-(1-7) was effectively blocked by [7-D-Ala]-Ang-(1-7). The results indicate that the Ang-(1-7)-induced excitation of paraventricular neurones may be mediated by a distinct Ang-(1-7)-receptor and that [7-D-Ala]-Ang-(1-7) is a selective antagonist of this receptor.
已证明，八肽血管紧张素II（Ang II）及其N端七肽血管紧张素 -（1 - 7）[Ang -（1 - 7）]的微量离子导入应用可提高大鼠下丘脑室旁核神经元的放电频率。在本微量离子导入研究中，测试了血管紧张素类似物[7 - D - Ala] - Ang -（1 - 7）对Ang II和Ang -（1 - 7）诱导的室旁核神经元放电频率增加的影响。虽然对Ang II的反应未改变，但对Ang -（1 - 7）的反应被[7 - D - Ala] - Ang -（1 - 7）有效阻断。结果表明，Ang -（1 - 7）诱导的室旁核神经元兴奋可能由一种独特的Ang -（1 - 7）受体介导，且[7 - D - Ala] - Ang -（1 - 7）是该受体的选择性拮抗剂。
