Goldstein I, Gomez K, Copel J A
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063.
Ultrasound Obstet Gynecol. 1995 Jan;5(1):34-7. doi: 10.1046/j.1469-0705.1995.05010034.x.
The objective of the study was to obtain measurements of the fetal fifth finger, as a basis for further studies and for future comparison with fetuses with Down's syndrome. The study group included 173 karyotypically normal fetuses at 15-23 weeks' gestation. Routine biometric measurements were obtained on all, including biparietal diameter (BPD), femoral length (FL) and humeral length (HL), and the length of the fetal fifth finger. Linear growth of the fifth finger was observed across the range of gestational ages (GA), and a linear correlation was shown to exist between the length of the fifth finger and gestational age (y = -7.804 + 0.9079 x GA; r = 0.923; p < 0.0001), biparietal diameter (y = -3.7010 + 0.3043 x BPD; r = 0.913; p < 0.0001), femoral length (y = -0.0983 + 0.3406 x FL; r = 0.926; p < 0.0001), and humeral length (y = -1.3453 + 0.3982 x HL; r = 0.929; p < 0.0001). These results provide normative data of the length of the fetal fifth finger across a range of gestational ages. These data may provide an additional screening parameter for the prenatal detection of Down's syndrome.
本研究的目的是获取胎儿第五指的测量数据，作为进一步研究以及未来与唐氏综合征胎儿进行比较的基础。研究组包括173例孕15 - 23周染色体核型正常的胎儿。对所有胎儿均进行了常规生物测量，包括双顶径（BPD）、股骨长度（FL）和肱骨长度（HL），以及胎儿第五指的长度。在整个孕周范围内观察到第五指的线性生长，且第五指长度与孕周（y = -7.804 + 0.9079x孕周；r = 0.923；p < 0.0001）、双顶径（y = -3.7010 + 0.3043x BPD；r = 0.913；p < 0.0001）股骨长度（y = -0.0983 + 0.3406x FL；r = 0.926；p < 0.0001）和肱骨长度（y = -1.3453 + 0.3982x HL；r = 0.929；p < 0.0001）之间均显示存在线性相关性。这些结果提供了不同孕周胎儿第五指长度的标准数据。这些数据可能为唐氏综合征的产前检测提供一个额外的筛查参数。
