Sukcharoen N, Tannirandorn Y, Suwajanakorn S, Paosawadi S
Department of Obstetrics & Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1992 Aug;75(8):483-7.
Several ultrasonographic signs have been described in second-trimester Down's syndrome fetuses. Previously published reports have shown that fetuses affected with Down's syndrome have normal biparietal diameter (BPD), high BPD-to-femur length (FL) ratio, and low actual FL-to-expected FL ratio. A retrospective comparison of the BPD-to-FL ratio and actual FL-to-expected FL ratio was made between 3 fetuses with Down's syndrome diagnosed prenatally by second-trimester amniocentesis and 189 normal fetuses with gestational age varying from 13-25 weeks who were seen in the Ultrasound Unit of Department of Obstetrics & Gynaecology, Chulalongkorn Hospital between January 1, 1989 and May 31, 1990. The sensitivity of BPD-to-FL ratio and actual FL-to-expected FL ratio as a screening technique for Down's syndrome in this study was 66.7 and 100 per cent, with a specificity of 93.4 and 89.2 per cent respectively. These sonographic parameters appear to be a useful screening method for Down's syndrome.
孕中期唐氏综合征胎儿有几种超声征象已被描述。先前发表的报告显示，患唐氏综合征的胎儿双顶径（BPD）正常，双顶径与股骨长度（FL）之比高，实际股骨长度与预期股骨长度之比低。对1989年1月1日至1990年5月31日在朱拉隆功医院妇产科超声科检查的3例经孕中期羊膜腔穿刺术产前诊断为唐氏综合征的胎儿与189例孕龄在13 - 25周的正常胎儿的双顶径与股骨长度之比及实际股骨长度与预期股骨长度之比进行了回顾性比较。在本研究中，双顶径与股骨长度之比及实际股骨长度与预期股骨长度之比作为唐氏综合征筛查技术的敏感性分别为66.7%和100%，特异性分别为93.4%和89.2%。这些超声参数似乎是一种有用的唐氏综合征筛查方法。
