源自中国仓鼠自发性子宫平滑肌肉瘤的致瘤细胞的染色体特征

Chromosomal characteristics of tumorigenic cells derived from a spontaneous uterine leiomyosarcoma of the Chinese hamster.

作者信息

Tateno H, Yamada M, Funaki K

机构信息

Department of Biological Sciences, Asahikawa Medical College, Yonago, Japan.

出版信息

Cancer Genet Cytogenet. 1995 Jan;79(1):54-8. doi: 10.1016/0165-4608(94)00089-t.

DOI:10.1016/0165-4608(94)00089-t

PMID:7850752

Abstract

A tumorigenic cell line (CHAUT) derived from a spontaneous uterine leiomyosarcoma of the Chinese hamster was established, and two clones (CHAUT-C and CHAUT-G) were characterized cytogenetically by both G- and C-band techniques. In both clones, all cells analyzed (53 in the C clone and 65 in the G clone) were distributed within a diploid range (24-26) with a modal number of 25. Their karyotypes were also characterized by four common changes; translocation of heterochromatic segment onto chromosome 2, tetrasomy of chromosome 10, monosomy of X chromosome, and one to three additional marker chromosomes of unknown origin.

摘要

建立了一种源自中国仓鼠自发性子宫平滑肌肉瘤的致瘤细胞系（CHAUT），并通过G带和C带技术对两个克隆（CHAUT-C和CHAUT-G）进行了细胞遗传学特征分析。在这两个克隆中，所有分析的细胞（C克隆中有53个，G克隆中有65个）都分布在二倍体范围内（24 - 26），众数为25。它们的核型还具有四个共同变化；异染色质片段易位到2号染色体上、10号染色体四体性、X染色体单体性以及一到三条来源不明的额外标记染色体。