Kuroki F, Iida M, Tominaga M, Matsumoto T, Kanamoto K, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Dig Dis. 1994 Jul-Aug;12(4):248-54. doi: 10.1159/000171459.
We measured serum and red blood cell concentrations of vitamin E and serum lipid concentrations in 13 inpatients at the initial diagnosis of Crohn's disease and compared them with those of 12 healthy controls. Although the serum concentrations of vitamin E were significantly lower in the patients with Crohn's disease than in the controls, the red blood cell concentrations of this vitamin did not differ between the two groups. The serum concentrations of total lipids and total cholesterol were decreased in the patients with Crohn's disease. A significant correlation was found between the red blood cell concentration of vitamin E and the serum vitamin E/serum total lipids ratio in both the groups. There was no correlation between the Crohn's disease activity index and serum or red blood cell levels of vitamin E. These findings suggest that the lowered serum vitamin E levels in patients with Crohn's disease are a symptom of hypolipidemia, and that vitamin E deficiency may not actually become a serious problem in patients diagnosed with Crohn's disease.
我们测量了13例初诊克罗恩病住院患者的血清和红细胞维生素E浓度以及血清脂质浓度，并将其与12名健康对照者进行比较。尽管克罗恩病患者的血清维生素E浓度显著低于对照组，但两组间该维生素的红细胞浓度并无差异。克罗恩病患者的血清总脂质和总胆固醇浓度降低。两组中维生素E的红细胞浓度与血清维生素E/血清总脂质比值之间均存在显著相关性。克罗恩病活动指数与血清或红细胞维生素E水平之间无相关性。这些发现表明，克罗恩病患者血清维生素E水平降低是低脂血症的一种表现，且维生素E缺乏在确诊为克罗恩病的患者中可能实际上并非严重问题。
