Marotta F, Labadarios D, Frazer L, Girdwood A, Marks I N
Gastrointestinal Clinic, Groote Schuur Hospital, Cape Town, South Africa.
Dig Dis Sci. 1994 May;39(5):993-8. doi: 10.1007/BF02087550.
In order to study the fat-soluble vitamin concentration of patients with chronic alcohol-induced pancreatitis (CAIP) we measured vitamins A and E, total lipids, and retinol-binding protein (RBP) in the plasma of 44 patients with CAIP and 83 controls (44 healthy controls; 39 Crohn's disease patients). Mean plasma vitamin E and vitamin E/total lipid ratio were significantly lower in CAIP when compared with either control or Crohn's disease groups. A low vitamin E/total lipid ratio was found in 75% of CAIP patients (91% with steatorrhea) and a ratio less than 1.0 was virtually 100% predictive of steatorrhea. The mean plasma vitamin A level for the CAIP group was significantly lower (overall 16%, 38% with steatorrhea) than in controls. Patients with CAIP show subnormal plasma levels vitamin E more often as compared to vitamin A. Further, the plasma vitamin E/total lipids ratio may be a sensitive and practical means in the detection and follow-up of steatorrhea in these patients.
为了研究慢性酒精性胰腺炎（CAIP）患者的脂溶性维生素浓度，我们测定了44例CAIP患者及83名对照者（44名健康对照者；39例克罗恩病患者）血浆中的维生素A和维生素E、总脂质以及视黄醇结合蛋白（RBP）。与对照组或克罗恩病组相比，CAIP患者的血浆维生素E及维生素E/总脂质比值显著降低。75%的CAIP患者维生素E/总脂质比值较低（脂肪泻患者中91%），比值小于1.0实际上对脂肪泻的预测率达100%。CAIP组的平均血浆维生素A水平显著低于对照组（总体低16%，脂肪泻患者中低38%）。与维生素A相比，CAIP患者血浆维生素E水平更常低于正常。此外，血浆维生素E/总脂质比值可能是检测和随访这些患者脂肪泻的一种敏感且实用的方法。
