Imes S, Pinchbeck B, Dinwoodie A, Walker K, Thomson A B
Department of Medicine and Laboratory Medicine, University of Alberta, Edmonton, Canada.
Digestion. 1987;37(3):166-70. doi: 10.1159/000199495.
Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 patients who completed 48-hour stool collections, 41% had stool fat values exceeding the reference value. Serum retinol concentrations were not significantly correlated with the serum carotene concentrations, with the 48-hour stool fat content, or with the Crohn's disease activity. In contrast serum retinol concentrations were correlated with the dietary levels of vitamin A. Serum carotene concentrations were inversely correlated with the stool fat content but were not related to Crohn's disease activity or dietary levels of carotene or total vitamin A. Thus: (1) serum retinol concentrations were normal in this moderately large group of patients with Crohn's disease and did not reflect a low dietary vitamin A intake by 34% of the population; (2) serum carotene levels were frequently low in patients with Crohn's disease, possibly due to the presence of steatorrhea, but were not related to low dietary intakes of carotene or to active Crohn's disease, and (3) a low serum level of carotene does not indicate that the patient is at risk of developing vitamin A deficiency.
在6个月的时间里，对137名克罗恩病门诊患者的血清视黄醇和血清胡萝卜素浓度进行了测定。在每个评估期，所有患者的血清视黄醇测量值均在参考范围内，而约四分之一患者的血清胡萝卜素水平较低。在完成48小时粪便收集的56名患者中，41%的患者粪便脂肪值超过参考值。血清视黄醇浓度与血清胡萝卜素浓度、48小时粪便脂肪含量或克罗恩病活动度均无显著相关性。相比之下，血清视黄醇浓度与维生素A的饮食摄入量相关。血清胡萝卜素浓度与粪便脂肪含量呈负相关，但与克罗恩病活动度、胡萝卜素或总维生素A的饮食摄入量无关。因此：（1）在这一中度规模的克罗恩病患者群体中，血清视黄醇浓度正常，并未反映出34%的人群饮食中维生素A摄入量低的情况；（2）克罗恩病患者的血清胡萝卜素水平经常较低，可能是由于脂肪泻的存在，但与胡萝卜素的低饮食摄入量或活动性克罗恩病无关，（3）血清胡萝卜素水平低并不表明患者有患维生素A缺乏症的风险。
