颅缝早闭的二元性及影像学可识别性
Binary nature and radiographic identifiability of craniosynostosis.
作者信息
Pilgram T K, Vannier M W, Marsh J L, Kraemer B B, Rayne S C, Gado M H, Moran C J, McAlister W H, Shackelford G D, Hardesty R A
机构信息
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
出版信息
Invest Radiol. 1994 Oct;29(10):890-6. doi: 10.1097/00004424-199410000-00005.
RATIONALE AND OBJECTIVES
Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error.
METHODS
Surgical reports, histology of excised sutures, and three-dimensional CT images were compared for 25 children undergoing surgical management of craniosynostosis. Surgical reports identified sutures as normal or abnormal. Histology reported suture closure on a 5-point scale. Four radiologists used three-dimensional CT images to diagnose sutures on a 6-point rated response scale.
RESULTS
Sutures with histology 0, 1, or 2 were normal on surgical reports, and those with histology 3 or 4 were abnormal. Most readers achieved nearly perfect sensitivity and specificity. Reader confidence was unrelated to degree of pathology.
CONCLUSION
Craniosynostosis appears to be binary in our sample. Surgical reports, pathology results, and three-dimensional CT images read by experienced viewers achieved nearly perfect agreement.
原理与目的
采用两个独立的金标准以及来自三维计算机断层扫描（CT）图像的诊断结果，来检验颅缝早闭是否为一种可能可无误诊断的二元异常情况。
方法
对25例接受颅缝早闭手术治疗的儿童的手术报告、切除缝线的组织学检查结果以及三维CT图像进行了比较。手术报告将缝线判定为正常或异常。组织学检查以5分制报告缝线闭合情况。四位放射科医生使用三维CT图像，按照6分制评分反应量表对缝线进行诊断。
结果
组织学评分为0、1或2的缝线在手术报告中为正常，组织学评分为3或4的缝线则为异常。大多数读者的敏感性和特异性几乎达到完美。读者信心与病理程度无关。
结论
在我们的样本中，颅缝早闭似乎是二元性的。手术报告、病理结果以及由经验丰富的观察者解读的三维CT图像达成了几乎完美的一致性。
Zotero 插件